It's a comprehensive question of the language of development. How fast does an annotation affect the execution speed?

I was practicing coding and suddenly got curious, so I'm leaving a question. I usually practice with Python. When it's hard to tell or when you need a lot of explanation, I tend to add a lot of comments. But if it affects the performance a little bit, I'm not sure if I should lose weight. I wonder how much the annotation affects the speed at which the program runs.